Hybrid modeling supported development of an industrial small-molecule flow chemistry process
Continuous manufacturing of small molecules finds increasing application in developing novel processes due to its significant advantages. The development of these processes is increasingly being
supported by models, in a quest to reduce the number of experiments and increase insight. With the Quality by Design paradigm in mind, answers to questions anent the impact of changes in process
parameters and material attributes on the process performance and product quality are sought to be answered.
In this contribution, a hybrid model is used to describe the impact of raw material variations and process parameter changes on the product quantity and quality of flow chemistry process. The
process model is then used for process optimization aiming at maximizing the product concentration. During the optimization, a constraint that accounts for the risk of model misprediction is
considered to explore only process conditions for which the model can describe the process behavior. The obtained optimal conditions are in agreement with expectations and underline the potential
for hybrid model-based process development.