Our project activities started in the framework of research collaborations between ETH Zurich and industrial partners in 2014. Since the end of 2017, our spin-off company DataHow AG is leading all industrial and academic project collaborations. The following list presents a selection of disclosable projects, some of which can be accessed in more detail through our research publications.

Our team has a long-standing experience in the modeling and design of various engineering systems. Since 2014, multivariate data analysis and machine learning have been increasingly integrated into our activities. The following list presents a selection of central publications of our team members.

General and Opinion Publications

1. Big data in biopharmaceutical process development – vice or virtue?, Sokolov, M., Feidl F., Morbidelli, M., Butté, A., Chem. Today (2018)  

Cell Culture Processes

1. Sequential multivariate cell culture modeling at multiple scales supports systematic shaping of a monoclonal antibody towards a quality target. Sokolov, M., Morbidelli, M., Butté, A., Souquet, J., & Broly, H., Biotechnology journal (2017).
2. Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality. Sokolov, M., Ritscher, J., MacKinnon, N., Souquet, J., Broly, H., Morbidelli, M., & Butté, A., Biotechnol. Prog., (2017).
3. Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality. Brühlmann, D., Sokolov, M., Butté, A., Sauer, M., Hemberger, J., Souquet, J., Broly, H. and Jordan, M., Biotechnol. Bioeng, (2017).
4. Robust parameter selection in early cell culture process development for the production of a biosimilar monoclonal antibody. Sokolov M., Ritscher J., MacKinnon N., Bielser J.-M., Brühlmann D., Rothenhäusler D., Thanei G., Soos, M., Stettler M., Souquet J., Broly H., Morbidelli M., Butté A., Biotechnol. Prog., (2016).
5. Fingerprint detection and process prediction by multivariate analysis of fed-batch monoclonal antibody cell culture data. Sokolov M., Soos M., Leardi R., Neunstoecklin B., Solacroup T., Stettler M., Broly H., Morbidelli M., Butté A., Biotechnol. Prog. 31:1623-1632, (2015).
   

Microbial Bioprocesses

Integrated Continuous Bioprocesses

1. Process performance and product quality in an integrated continuous antibody production process. Karst, D. J., Steinebach, F., Soos, M. and Morbidelli, M. (2017). Biotechnol. Bioeng., 114: 298–307.
2. Design and operation of a continuous integrated monoclonal antibody production process. Steinebach, F., Ulmer, N., Wolf, M., Decker, L., Schneider, V., Wälchli, R., Karst, D., Souquet, J. and Morbidelli, M. (2017), Biotechnol Progress, 33: 1303–1313.

Protein and Peptide Chromatography

1. Model-based description of peptide retention on doped reversed-phase media, R. Khalaf, N. Forrer, G. Buffolino, A. Butté, M. Morbidelli, J. Chromatogr. A, 1407, 169 (2015)
2. Reactive Peptide Nanofiltration, P. Marchetti, A. Butté, A. Livingston, ACS Symposium Series, 1124, 121 (2013)
3. Model-based design space determination of peptide chromatographic purification processes, D. Getaz, A. Butté, M. Morbidelli, , J. Chromatogr. A, 1284, 80 (2013)
4. Modeling of ion-pairing effect in peptide reversed-phase chromatography, D. Getaz, S.B. Hariharan, A. Butté, M. Morbidelli,. J. Chromatogr. A, 1249, 92 (2012)
5. A new versatile process for peptide purification using centrifugal partition chromatography, L. Boudesoque, N. Amarouche, P. Lameiras, J.M. Nuzillard, M. Giraud, J. McGarrity, F. Quattrini, A. Butté, J.H. Renault, Biopolymers, 96, 429 (2011)
6. Role of the ligand density in cation exchange materials for the purification of proteins, A. Franke, N. Forrer, A. Butté, B. Cvijetić, M. Morbidelli, M. Jöhnck, M. Schulte, J. Chromatogr. A, 1217, 2216 (2010)
7. Preparative Weak Cation-Exchange Chromatography of Monoclonal Antibody Variants. 1. Single Component Adsorption,   L. Melter, A. Butté, M. Morbidelli, , J. Chromatogr. A, 1200, 156 (2008)
8. Chromatographic behavior of a polyclonal IgG mixture on a strong cation exchanger column. Part II: Adsorption Modeling, N. Forrer, A. Butté, M. Morbidelli, , J. Chromatogr. A, 1214, 71 (2008)
9. Modeling of the Chromatographic Solvent Gradient Reverse Phase Purification of a Multicomponent Polypeptide Mixture, L. Aumann, A. Butté, M. Mazzotti, M. Morbidelli, B. Schenkel, K. Büscher, , Sep. Sci. Technol., 43, 1310 (2008)
   

Polymer Reaction Engineering

1. PNIPAAM Grafted Polymeric Monoliths Synthesized by Reactive Gelation Process and Their Swelling Deswelling Characteristics, V. Mittal, N.B. Matsko, A. Butté, M. Morbidelli, Macromol. Rea. Eng., 2, 215 (2008)
2. RAFT Polymerization in Bulk and Emulsion, A. Butté, A.D. Peklak, G. Storti, M. Morbidelli, Macromol. Symp.,248, 168 (2007)
3. Functionalized polystyrene latex particles as substrates for ATRP: Surface and colloidal characterization, V. Mittal, N.B. Matsko, A. Butté, M. Morbidelli, Polymer, 48, 2806 (2007)
4. Production of Polymeric Materials with Controlled Pore Structure: the Reactive Gelation Process, N. Marti, F. Quattrini, A. Butté, G. Storti and M. Morbidelli, Macromol. Mat. Eng., 290, 221 (2005)
5. Miniemulsion Living Free Radical Polymerization by RAFT, A. Butté, G. Storti, M. Morbidelli, , Macromolecules, 34, 5885 (2001)
6. Kinetics of living free radical polymerization, A. Butté, G. Storti, M. Morbidelli, Chem. Eng. Sci., 54, 3225 (1999).