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Blog
01/26/2023 - Comparison of strategies for iterative model-based upstream bioprocess development with single and parallel reactor set-ups
01/18/2023 - How to select the right approach or solution for your digitalization plan?
01/10/2023 - Digital with a purpose
12/31/2022 - Hybrid modeling supported development of an industrial small-molecule flow chemistry process
02/15/2022 - Functional-Hybrid modeling through automated adaptive symbolic regression for interpretable mathematical expressions
12/01/2021 - Hybrid modeling — a key enabler towards realizing digital twins in biopharma?
09/14/2021 - Design of Biopharmaceutical Formulations Accelerated by Machine Learning
09/01/2021 - Modeling of Continuous PHA Production by a Hybrid Approach Based on First Principles and Machine Learning
09/01/2021 - A roadmap to AI-driven in silico process development: bioprocessing 4.0 in practice
08/03/2021 - Knowledge transfer across cell lines using hybrid Gaussian process models with entity embedding vectors
08/02/2021 - Hybrid Models for the simulation and prediction of chromatographic processes for protein capture
07/06/2021 - Hybrid Models Based on Machine Learning and an Increasing Degree of Process Knowledge: Application to Capture Chromatographic Step
03/01/2021 - Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation
12/30/2020 - Potential of Integrating Model-Based Design of Experiments Approaches and Process Analytical Technologies for Bioprocess Scale-Down
11/20/2020 - Automated Conditional Screening of Multiple Escherichia coli Strains in Parallel Adaptive Fed-Batch Cultivations
10/19/2020 - From Screening to Production: a Holistic Approach of High-throughput Model-based Screening for Recombinant Protein Production
09/17/2020 - Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations
09/08/2020 - Decision Making and Risk Management in Biopharmaceutical Engineering—Opportunities in the Age of Covid-19 and Digitalization
09/01/2020 - Insights into the dynamics and control of COVID-19 infection rates
08/16/2020 - Model based strategies towards protein A resin lifetime optimization and supervision
07/18/2020 - Probabilistic Modeling for Optimization of Bioreactors using Reinforcement Learning with Active Inference
06/17/2020 - Working within the Design Space: Do Our Static Process Characterization Methods Suffice?
05/18/2020 - Model reduction of aerobic bioprocess models for efficient simulation
05/14/2020 - Monitoring Parallel Robotic Cultivations with Online Multivariate Analysis
02/05/2020 - Process-wide control and automation of an integrated continuous manufacturing platform for antibodies
10/01/2019 - Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification
09/05/2019 - Bioprocessing in the Digital Age: The Role of Process Models
07/17/2019 - A model-based framework for parallel scale-down fed-batch cultivations in mini-bioreactors for accelerated phenotyping
07/09/2019 - Integrated Robotic Mini Bioreactor Platform for Automated, Parallel Microbial Cultivation With Online Data Handling and Process Control
06/25/2019 - A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins
06/19/2019 - Dynamic Modelling of Phosphorolytic Cleavage Catalyzed by Pyrimidine-Nucleoside Phosphorylase
05/24/2019 - Monte Carlo Simulations for the Analysis of Non-linear Parameter Confidence Intervals in Optimal Experimental Design
05/17/2019 - A new flow cell and chemometric protocol for implementing in-line Raman spectroscopy in chromatography
04/10/2019 - Decision Tree-PLS (DT-PLS) algorithm for the development of process: Specific local prediction models
01/01/2019 - Digitalization platform and supervisory control of an integrated continuous bioprocess
11/21/2018 - Accelerated Bioprocess Development of Endopolygalacturonase - Production with Saccharomyces cerevisiae
11/01/2018 - Big data in biopharmaceutical process development vice or virtue?
05/06/2018 - Generating glycan variants for biological activity
12/28/2017 - Sequential Multivariate Cell Culture Modeling
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